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Cost of generic atorvastatin is higher in Canada than the United States and is a key reason why the treatment is used less broadly worldwide than in the US [29]. contrast, lower price of atorvastatin in Canada is considered to be one of its therapeutic advantages in Canada compared to the USA [33]. One recent study found that Canadian patients were more willing to pay for generic atorvastatin than those in the USA [34] and that higher prices in the US may represent a higher barrier to generic entry, which could contribute to lower prices in Canada compared to the USA [27]. Other important reasons why lower prices are not implemented include financial constraints and difficulty of negotiating with the manufacturer. respect to financial constraints, the US manufacturer pays Canada less to produce the drug, which is expected to result in lower prices Canada. To be competitive, Canada has a limited number of generic drug manufacturers in the country and may cost of atorvastatin 20 mg uk find it difficult to negotiate lower prices with a single manufacturer, since some of the companies that produce generic drugs are located in regions where there is little competition [10]. Similarly, it may also be difficult to negotiate lower prices with one distributor in Canada due to the small number of pharmacies that sell generics and the difficulty in finding distributors that are willing to sell the drug. There may also be a barrier to implementing lower prices because of difficulties in getting approval from the government to use drugs that contain recombinant DNA technology. In the mid-1990s, FDA did not allow access to these drugs. The manufacturer may find it difficult to obtain approval or the drug may not be allowed for sale on the Canadian market due to human safety concerns, as was the case with atorvastatin. Finally, it has been criticized that the low cost of generic drugs in Canada could have significant implications for the pharmaceutical marketplace by reducing incentives for producers to develop new drugs or generics for existing therapies. While these concerns are not universally valid, they certainly relevant given the substantial growth in popularity of prescription drugs Canada [35] and the growing number of Canadians with chronic health problems [36]. Thus, in Canada, the cost of generic drugs is a matter of significant concern and one that will influence the development and use of new drugs as well the cost of older treatments. 5.1. Conclusion The use of generic versions antithrombotic agents in the US and other countries is a trend that will likely become predominant in the future. For US market, cost of generic atorvastatin is lower than in Canada, the situation is due partly to an absence of generic competition in the US, but a significant part of the cost differential is due to market exclusivity. For generics, Canada is a key country in which to negotiate. The lower cost of generic atorvastatin is seen as a contributing factor to the high use of atorvastatin in Canada, since the US cost per unit of atorvastatin is higher than in Canada. The price of generic atorvastatin in Canada has been increasing at the same time that least partial price discounts under the Affordable Care Act have occurred. In contrast, the price of generic atorvastatin in the Atorva $251 $76.33 - Per pill US has risen, while at the same time drug patent terms for atorvastatin have become increasingly long, limiting access to generic atorvastatin. As a result, the price of generic atorvastatin is lower than in the US, but use of generic atorvastatin in.
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